Molecular physiology of neuronal K-ATP channels
نویسندگان
چکیده
منابع مشابه
Molecular physiology of neuronal K-ATP channels (review).
ATP sensitive potassium (K-ATP) channels are widely expressed in many cell types including neurons. K-ATP channels are heteromeric membrane proteins that consist of two very different subunits: the pore-forming, two-transmembrane spanning potassium channel subunit (Kir6) and the regulatory, 17 transmembrane spanning sulphonylurea receptor (SUR). This ensemble--joined together in a 4:4 stoichiom...
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Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...
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ژورنال
عنوان ژورنال: Molecular Membrane Biology
سال: 2001
ISSN: 0968-7688,1464-5203
DOI: 10.1080/09687680110047373